There has been a general desire for many years for the utopian concept of a cheap, reliable, sensitive, specific serological test which could be performed in the most simply equiped laboratories, and many possibilities have been investigated, but in the real world, things are never quite what one hopped for.   

THE PROBLEMS OF DIAGNOSIS ARE SUCH THAT DIAGNOSIS IS BEST ESTABLISHED BY A COMBINATION OF AS MENY PARAMETERS AS POSSIBLE, HAVING DUE REGARD TO THE VALUE OF EACH FEATURE AT THE VARIOUS STAGES OF INFECTION.